International Society for Stem Cell Research
The International Society for Stem Cell Research is an independent, nonprofit organization established to promote and foster the exchange and dissemination of information and ideas relating to stem cells, to encourage the general field of research involving stem cells and to promote professional and public education in all areas of stem cell research and application.
Society For Hematology and Stem Cells (ISEH)
The Society for Hematology and Stem Cells (ISEH) was established in 1950 by a group of scientists who sought to create a forum for the presentation and discussion of pre-clinical data in experimental hematology. ISEH continues to be dedicated to the promotion of the scientific knowledge and clinical application of basic hematologic and immunologic disorders through research, publications, and scientific programs. Incorporated in 1972 in the USA, the Society has over 800 active members from 40 countries around the world. Its annual scientific meeting attracts more than 500 participants over 4 days and, together with its official monthly journal Experimental Hematology, provides essential delivery of quality education, training programs, discussion forums, as well as promotes basic research.
Mouse Genome Informatics
MGI is the international database resource for the laboratory mouse, providing integrated genetic, genomic, and biological data to facilitate the study of human health and disease. The projects contributing to this resource are:
Mouse Genome Database (MGD) Project
MGD includes data on gene characterization, nomenclature, mapping, gene homologies among mammals, sequence links, phenotypes, allelic variants and mutants, and strain data. See About MGD.
Gene Expression Database (GXD) Project
GXD integrates different types of gene expression information from the mouse and provides a searchable index of published experiments on endogenous gene expression during development. See Gene Expression Database (GXD) and About the Gene Expression Database (GXD).
Mouse Tumor Biology (MTB) Database Project
MTB integrates data on the frequency, incidence, genetics, and pathology of neoplastic disorders, emphasizing data on tumors that develop characteristically in different genetically defined strains of mice. See Welcome to the Mouse Tumor Biology (MTB) Database and Mouse Tumor Biology Database User Help Reference.
Gene Ontology (GO) Project at MGI
The Mouse Genome Informatics group is a founding member of the Gene Ontology Consortium (www.geneontology.org). MGI fully incorporates the GO in the database and provides a GO browser. See Functional Annotation using the Gene Ontology (GO) and The Gene Ontology (GO) Project.
MouseCyc Project at MGI
The MouseCyc database focuses on Mus musculus metabolism and includes cell level processes such as biosynthesis, degradation, energy production, and detoxification. It is part of the BioCyc (http://www.biocyc.org/) collection of pathway databases created at SRI International. Pathway information in MouseCyc is integrated with MGI data. See Mouse Cyc - Biochemical Pathways.
Ensembl Genome Browser
About the Ensembl Project
The Ensembl project was started in 1999, some years before the draft human genome was completed. Even at that early stage it was clear that manual annotation of 3 billion base pairs of sequence would not be able to offer researchers timely access to the latest data. The goal of Ensembl was therefore to automatically annotate the genome, integrate this annotation with other available biological data and make all this publicly available via the web. Since the website's launch in July 2000, many more genomes have been added to Ensembl and the range of available data has also expanded to include comparative genomics, variation and regulatory data.
The number of people involved in the project has also steadily increased. Currently, the Ensembl group consists of between 40 and 50 people, divided in a number of teams. The Genebuild team creates the gene sets for the various species. The result of their work is stored in the core databases, which are taken care of by the Software team. This team also develops and maintains the BioMart data mining tool. The Compara, Variation and Regulation teams are responsible for the comparative and the variation and regulatory data, respectively. The Web team makes sure that all data are presented on the website in a clear and user-friendly way. Finally the Outreach team answers questions from users and gives workshops worldwide about the use of Ensembl. The Ensembl project is headed by Paul Flicek and Steve Searle, and receives input from an independent scientific advisory board.
Ensembl is a joint project between European Bioinformatics Institute (EBI), an outstation of the European Molecular Biology Laboratory (EMBL), and the Wellcome Trust Sanger Institute (WTSI). Both institutes are located on the Wellcome Trust Genome Campus in Hinxton, south of the city of Cambridge, United Kingdom.
Assemblies and sequence
The DNA sequences and assemblies used in the Ensembl genebuild are provided by various projects around the world. Please see individual species' home pages for acknowledgements.
In order to improve consistency between the data provided by different genome browsers, Ensembl has entered into an agreement with UCSC and NCBI with regard to sequence identifiers:
• Browser Genome Release Agreemen
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